GnRH Receptor
Gonadotropin releasing hormone receptor; GNRHR
The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.
Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.
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GnRH Receptor Related Products (161)
Related Products (161)
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Antibodies (3)
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[D-Phe2,6, Pro3]-LH-RH
![[D-Phe2,6, Pro3]-LH-RH](https://file.medchemexpress.com/product_pic/hy-p3666.gif "Click to View [D-Phe2,6, Pro3]-LH-RH Product Detail")
0 ImagesCat. No.: HY-P3666CAS No.: 64789-67-9[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist.
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Onvitrelin ucalontide
0 ImagesCat. No.: HY-P4144CAS No.: 1174415-90-7Synonyms: Phor18-LHRH (338613); EP-100Onvitrelin ucalontide (Phor18-LHRH (338613); EP-100) is a luteinizing hormone-releasing hormone (LHRH) receptor ligand. Onvitrelin ucalontide binds to functional LHRH receptors on cancer cells and mediates targeted cytotoxicity. Onvitrelin ucalontide reduces tumor volume, weight and the number of viable tumor cells in xenograft models. Onvitrelin ucalontide can be used for the research of breast cancer, ovarian cancer and prostate cancer.
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GnRH antagonist 3
0 ImagesCat. No.: HY-P5897CAS No.: 292141-31-2GnRH antagonist 3 (Compound 11) is a GnRH antagonist with an IC50 of 7 nM. GnRH antagonist 3 can be used in the research of hormone-dependent diseases.
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Cetrorelix diacetate
0 ImagesCat. No.: HY-P0009BCAS No.: 130143-01-0Synonyms: SB-75 diacetateCetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
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[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH
![[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH](https://file.medchemexpress.com/product_pic/hy-p2082.gif "Click to View [D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH Product Detail")
0 ImagesCat. No.: HY-P2082CAS No.: 78255-70-6[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a gonadotropin-releasing hormone (Gn-RH) agonist that has a dose-dependent inhibitory activity on progesterone secretion from cultured human granulosa cells.
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DCOIT (Standard)
0 ImagesSynonyms: Kathon 930 (Standard)DCOIT (Standard) is the analytical standard of DCOIT. This product is intended for research and analytical applications. DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca2+ signaling cascades[1].
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Azaline
0 ImagesCat. No.: HY-P3317CAS No.: 134457-26-4Synonyms: Azaline AAzaline (Azaline A) is a gonadotropin-releasing hormone (GnRH) receptor antagonist with a KD value of 0.48 nM. Azaline can effectively induce histamine release, with an effect comparable to that of GnRH, and it can completely inhibit ovulation at a dose of 2.0-3.0 μg per female rat. Azaline has potential applications in regulating reproductive functions.
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Elagolix-d9
0 ImagesCat. No.: HY-115633SCAS No.: 2455524-81-7Elagolix-d9 is the deuterium labeled Elagolix. Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
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Lamprey LH-RH I
0 ImagesCat. No.: HY-P3673CAS No.: 102634-23-1Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models.
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Fertirelin acetate
0 ImagesCat. No.: HY-P0053ACAS No.: 66002-66-2Fertirelin acetate is a GnRH and LH-RH analogue. Fertirelin acetate can be used of the study for reversing cow follicular cysts.
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A-75998
0 ImagesCat. No.: HY-129593CAS No.: 135215-95-1A-75998 is an antagonist of luteinizing hormone-releasing hormone (LHRH). A-75998 can be used in the research of diseases such as hormone-sensitive cancers and endometriosis.
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WAY-207024
0 ImagesCat. No.: HY-12096CAS No.: 872002-72-7WAY-207024 is an orally active gonadotropin releasing hormone receptor (GnRH-R) antagonist (human GnRH: IC50 of 12 nM, rat GnRH: IC50 of 71 nM). WAY-207024 inhibits rat LH release with an IC50 of 350 nM. WAY-207024 lowers rat plasma leuteinizing hormone (LH) levels after oral administration.
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(D-Leu6)-LHRH (1-8)
0 ImagesCat. No.: HY-P4536CAS No.: 112642-14-5(D-Leu6)-LHRH (1-8) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
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Acyline
0 ImagesAcyline, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels.
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WAY-207024 dihydrochloride
0 ImagesCat. No.: HY-12096ACAS No.: 872002-73-8WAY-207024 dihydrochloride is an orally active gonadotropin releasing hormone receptor (GnRH-R) antagonist (human GnRH: IC50 of 12 nM, rat GnRH: IC50 of 71 nM). WAY-207024 dihydrochloride inhibits rat LH release with an IC50 of 350 nM. WAY-207024 dihydrochloride lowers rat plasma leuteinizing hormone (LH) levels after oral administration.
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(D-His2)-Goserelin
0 ImagesCat. No.: HY-P4759CAS No.: 1926163-37-2(D-His2)-Goserelin is a derivative of Goserelin, a decapeptide analog of gonadotropin-releasing hormone (GnRH/LHRH).
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(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH
0 ImagesCat. No.: HY-P4442CAS No.: 1872435-01-2(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
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LH-RH (7-10)
0 ImagesCat. No.: HY-P3674CAS No.: 38482-71-2LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.
