2. Signaling Pathways
  3. GPCR/G Protein
  4. GnRH Receptor

GnRH Receptor

Gonadotropin releasing hormone receptor; GNRHR

GnRH Receptor

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The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.

Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3673
    Lamprey LH-RH I
    		Activator
    Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models.
    Lamprey LH-RH I
  • HY-P0053A
    Fertirelin acetate
    		Agonist
    Fertirelin acetate is a GnRH and LH-RH analogue. Fertirelin acetate can be used of the study for reversing cow follicular cysts.
    Fertirelin acetate
  • HY-129593
    A-75998
    A-75998 is an antagonist of luteinizing hormone-releasing hormone (LHRH). A-75998 can be used in the research of diseases such as hormone-sensitive cancers and endometriosis.
    A-75998
  • HY-12096
    WAY-207024
    		Antagonist
    WAY-207024 is an orally active gonadotropin releasing hormone receptor (GnRH-R) antagonist (human GnRH: IC50 of 12 nM, rat GnRH: IC50 of 71 nM). WAY-207024 inhibits rat LH release with an IC50 of 350 nM. WAY-207024 lowers rat plasma leuteinizing hormone (LH) levels after oral administration.
    WAY-207024
  • HY-P4536
    (D-Leu6)-LHRH (1-8)
    (D-Leu6)-LHRH (1-8) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (D-Leu6)-LHRH (1-8)
  • HY-16027
    Acyline
    		Antagonist 99.52%
    Acyline, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels.
    Acyline
  • HY-12096A
    WAY-207024 dihydrochloride
    		Agonist
    WAY-207024 dihydrochloride is an orally active gonadotropin releasing hormone receptor (GnRH-R) antagonist (human GnRH: IC50 of 12 nM, rat GnRH: IC50 of 71 nM). WAY-207024 dihydrochloride inhibits rat LH release with an IC50 of 350 nM. WAY-207024 dihydrochloride lowers rat plasma leuteinizing hormone (LH) levels after oral administration.
    WAY-207024 dihydrochloride
  • HY-P11810
    GUB08248
    		Agonist
    GUB08248 is a full GPR10 agonist and a partial NPFF2R agonist, with EC50 values of 0.5 nM and 2.5 nM, respectively. GUB08248 inhibits food intake and induces sustained weight loss. GUB08248 can be used in obesity-related research.
    GUB08248
  • HY-P4759
    (D-His2)-Goserelin
    (D-His2)-Goserelin is a derivative of Goserelin, a decapeptide analog of gonadotropin-releasing hormone (GnRH/LHRH).
    (D-His2)-Goserelin
  • HY-125611
    Fluorogestone acetate
    		99.60%
    Fluorogestone acetate is a progesterone compound. Fluorogestone acetate inhibits ovulation and synchronizes the estrous cycle in cattle by inhibiting the release of luteinizing hormone (LH) from the pituitary gland.
    Fluorogestone acetate
  • HY-P4442
    (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH
    (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH
  • HY-P3674
    LH-RH (7-10)
    		Activator
    LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.
    LH-RH (7-10)
  • HY-P4467
    (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
    (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
  • HY-P3663
    [Lys8] LH-RH
    		Activator
    [Lys8] LH-RH is a analogue of LH-RH. [Lys8] LH-RH stimulates LH and FSH release.
    [Lys8] LH-RH
  • HY-16375
    Ozarelix
    		Antagonist
    Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer.
    Ozarelix
  • HY-P10472
    Azaline B
    		Antagonist
    Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception.
    Azaline B
  • HY-P992149
    Lutropin alfa
    Lutropin alfa is a recombinant human luteinizing hormone (LH). Lutropin alfa consists of non-covalently linked α and β subunits, and its activity is similar to that of natural luteinizing hormone. Lutropin alfa is used to stimulate follicular development in infertility.
    Lutropin alfa
  • HY-P4577
    (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
    (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
    (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
  • HY-P4441
    (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH
    (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH
  • HY-P4570
    (D-Ser6,Azagly10)-LHRH
    (D-Ser6,Azagly10)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (D-Ser6,Azagly10)-LHRH
Cat. No. Product Name / Synonyms Application Reactivity